The Mitte Museum is the regional history museum for the Berlin districts of Mitte, Tiergarten, and Wedding, established in 2004 through the merging of their three local museums. It is located in a listed school building from 1866 on Pankstraße, renovated from 2016 to 2019. The permanent exhibition opened in 2021 addresses the district's history in several thematic rooms.

In addition to the permanent exhibition, the Mitte Museum presents changing special exhibitions. Educational programs are aimed at children and teenagers.